Evaluation of Peripheral Blood Concentrations of Phoenixin, Spexin, Nesfatin-1 and Kisspeptin as Potential Biomarkers of Bipolar <span style="font-variant: small-caps">D</span>isorder in the Pediatric Population
Lena Cichoń,
Artur Pałasz,
Krzysztof M. Wilczyński,
Aleksandra Suszka-Świtek,
Anna Żmijowska,
Ireneusz Jelonek,
Małgorzata Janas-Kozik
Affiliations
Lena Cichoń
Department of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, Poland
Artur Pałasz
Department of Histology, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Medyków 18, 40-752 Katowice, Poland
Krzysztof M. Wilczyński
Department of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, Poland
Aleksandra Suszka-Świtek
Department of Histology, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Medyków 18, 40-752 Katowice, Poland
Anna Żmijowska
Department of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, Poland
Ireneusz Jelonek
Department of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, Poland
Małgorzata Janas-Kozik
Department of Developmental Age Psychiatry and Psychotherapy, John Paul II Pediatric Centre in Sosnowiec, Faculty of Medical Sciences, Medical University of Silesia in Katowice, ul. Zapolskiej 3, 41-218 Sosnowiec, Poland
There are some initial suggestions in the literature that phoenixin, spexin, nesfatin-1 and kisspeptin may play a role in the pathogenesis of affective disorders. Therefore, they may also be cautiously considered as potential diagnostic or predictive biomarkers of BD. This study aimed to evaluate the levels of the aforementioned neuropeptides in the peripheral blood of children and adolescents with bipolar. This study included 122 individuals: 67 persons with diagnosed bipolar disorder types I and II constituted the study group, and 55 healthy persons were included in the control group. Statistically significant differences in the concentrations of neuropeptides between the control and study groups were noted in relation to nesfatin-1 and spexin (although spexin lost statistical significance after introducing the Bonferroni correction). In a logistic regression analysis, an increased risk of bipolar disorder was noted for a decrease in nesfatin-1 concentration. Lower levels of nesfatin-1 seemed to be a significant risk factor for the development of bipolar disorder types I and II. Furthermore, the occurrence of bipolar disorder was associated with significantly elevated levels of spexin. None of the analyzed neuropeptides was significantly correlated with the number of symptoms of bipolar disorder.
