Design, synthesis of novel azo derivatives of benzimidazole as potent antibacterial and anti tubercular agents

Abstract

A series of some novel azo derivatives of benzimidazole were prepared by coupling diazonium derivative of benzimidazole with various appropriate aromatic compounds. Confirmation of the chemical structure of the novel synthesized compounds 6a (1–5) & 6b (1–5) was substantiated by TLC, different spectral data IR, 1H NMR, Mass spectra and elemental analysis. The synthesized compounds were evaluated for in-vitro antimicrobial and anti tubercular activities against Bacillus subtilis, Escherichia coli and Mycobacterium tuberculosis. The compounds exhibited weak, moderate, or high in-vitro antimicrobial and anti tubercular potency. Compounds 6a2, 6a3, 6b2 and 6b3 exhibited potential antimicrobial activity. Keywords: Azo derivatives, Benzimidazole, Antimicrobial and anti tubercular