The IAP family member BRUCE regulates autophagosome–lysosome fusion

Petra Ebner; Isabella Poetsch; Luiza Deszcz; Thomas Hoffmann; Johannes Zuber; Fumiyo Ikeda

doi:10.1038/s41467-018-02823-x

Nature Communications (Feb 2018)

The IAP family member BRUCE regulates autophagosome–lysosome fusion

Petra Ebner,
Isabella Poetsch,
Luiza Deszcz,
Thomas Hoffmann,
Johannes Zuber,
Fumiyo Ikeda

Affiliations

Petra Ebner: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Isabella Poetsch: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Luiza Deszcz: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)
Thomas Hoffmann: Research Institute of Molecular Pathology (IMP)
Johannes Zuber: Research Institute of Molecular Pathology (IMP)
Fumiyo Ikeda: Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA)

DOI: https://doi.org/10.1038/s41467-018-02823-x
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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The inhibitor of apoptosis (IAP) protein, BRUCE is known to ubiquitinate apoptosis regulators for proteasomal degradation. Here the authors show that BRUCE provides a bridge between LAMP2 on lysosomes and Atg8 family proteins on autophagosomes to support autophagosome-lysosome fusion.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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