Nature Communications (Jun 2019)
Common and distinct transcriptional signatures of mammalian embryonic lethality
- John E. Collins,
- Richard J. White,
- Nicole Staudt,
- Ian M. Sealy,
- Ian Packham,
- Neha Wali,
- Catherine Tudor,
- Cecilia Mazzeo,
- Angela Green,
- Emma Siragher,
- Edward Ryder,
- Jacqueline K. White,
- Irene Papatheodoru,
- Amy Tang,
- Anja Füllgrabe,
- Konstantinos Billis,
- Stefan H. Geyer,
- Wolfgang J. Weninger,
- Antonella Galli,
- Myriam Hemberger,
- Derek L. Stemple,
- Elizabeth Robertson,
- James C. Smith,
- Timothy Mohun,
- David J. Adams,
- Elisabeth M. Busch-Nentwich
Affiliations
- John E. Collins
- Wellcome Sanger Institute, Wellcome Genome Campus
- Richard J. White
- Wellcome Sanger Institute, Wellcome Genome Campus
- Nicole Staudt
- Wellcome Sanger Institute, Wellcome Genome Campus
- Ian M. Sealy
- Wellcome Sanger Institute, Wellcome Genome Campus
- Ian Packham
- Wellcome Sanger Institute, Wellcome Genome Campus
- Neha Wali
- Wellcome Sanger Institute, Wellcome Genome Campus
- Catherine Tudor
- Wellcome Sanger Institute, Wellcome Genome Campus
- Cecilia Mazzeo
- Wellcome Sanger Institute, Wellcome Genome Campus
- Angela Green
- Wellcome Sanger Institute, Wellcome Genome Campus
- Emma Siragher
- Wellcome Sanger Institute, Wellcome Genome Campus
- Edward Ryder
- Wellcome Sanger Institute, Wellcome Genome Campus
- Jacqueline K. White
- Wellcome Sanger Institute, Wellcome Genome Campus
- Irene Papatheodoru
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Amy Tang
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Anja Füllgrabe
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Konstantinos Billis
- European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus
- Stefan H. Geyer
- Division of Anatomy, MIC, Medical University of Vienna
- Wolfgang J. Weninger
- Division of Anatomy, MIC, Medical University of Vienna
- Antonella Galli
- Wellcome Sanger Institute, Wellcome Genome Campus
- Myriam Hemberger
- The Babraham Institute, Babraham Research Campus
- Derek L. Stemple
- Wellcome Sanger Institute, Wellcome Genome Campus
- Elizabeth Robertson
- Sir William Dunn School of Pathology, University of Oxford
- James C. Smith
- The Francis Crick Institute
- Timothy Mohun
- The Francis Crick Institute
- David J. Adams
- Wellcome Sanger Institute, Wellcome Genome Campus
- Elisabeth M. Busch-Nentwich
- Wellcome Sanger Institute, Wellcome Genome Campus
- DOI
- https://doi.org/10.1038/s41467-019-10642-x
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 16
Abstract
The transcriptional signature of embryonic lethality has not been defined. Here, the authors, as part of the Deciphering the Mechanisms of Developmental Disorders programme, define genes causing murine embryonic lethality around E9.5 and identify developmental delay transcriptional signatures.
