Himalayan <i>Ficus palmata</i> L. Fruit Extract Showed In Vivo Central and Peripheral Analgesic Activity Involving COX-2 and Mu Opioid Receptors

Abstract

Analgesic drugs like morphine and non-steroidal anti-inflammatory drugs exhibit several harmful effects. Here, we show for the first time the analgesic activity of Ficus palmata L. fruit extract (FPFE) on different analgesic rat models along with the in silico studies of some of the main phytochemicals of this plant. We performed in vivo pain models, along with in silico docking studies against the active site of COX-2 protein and mu-opioid receptors. A significant (p F. palmata fruits have the potential to ameliorate painful conditions.

Keywords

• <i>Ficus</i>
• pain
• hot plate
• formalin
• cyclooxygenase
• neurogenic