Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer

Gowravaram Sabitha; Rangavajjula Srinivas; Sukant K. Das; Jhillu S. Yadav

doi:10.3762/bjoc.6.8

Beilstein Journal of Organic Chemistry (Jan 2010)

Synthesis of (3R,5R)-harzialactone A and its (3R,5S)-isomer

Gowravaram Sabitha,
Rangavajjula Srinivas,
Sukant K. Das,
Jhillu S. Yadav

Affiliations

Gowravaram Sabitha: Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512
Rangavajjula Srinivas: Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512
Sukant K. Das: Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512
Jhillu S. Yadav: Organic Division I, Indian Institute of Chemical Technology, Hyderabad 500 007, India, Fax: +91-40-27160512

DOI: https://doi.org/10.3762/bjoc.6.8
Journal volume & issue: Vol. 6, no. 1
p. 8

Abstract

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The total synthesis of (3R,5R)-harzialactone A (1) and its (3R,5S)-isomer (2) is described. Epoxide opening with thioacetal and diastereoselective reductions are used as key reactions.

Published in Beilstein Journal of Organic Chemistry

ISSN: 1860-5397 (Online)
Publisher: Beilstein-Institut
Country of publisher: Germany
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.beilstein-journals.org/bjoc

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