Nature Communications (Dec 2018)
Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens
- Sylvain Normand,
- Nadine Waldschmitt,
- Andreas Neerincx,
- Ruben Julio Martinez-Torres,
- Camille Chauvin,
- Aurélie Couturier-Maillard,
- Olivier Boulard,
- Laetitia Cobret,
- Fawaz Awad,
- Ludovic Huot,
- Andre Ribeiro-Ribeiro,
- Katja Lautz,
- Richard Ruez,
- Myriam Delacre,
- Clovis Bondu,
- Martin Guilliams,
- Charlotte Scott,
- Anthony Segal,
- Serge Amselem,
- David Hot,
- Sonia Karabina,
- Erwin Bohn,
- Bernhard Ryffel,
- Lionel F. Poulin,
- Thomas A. Kufer,
- Mathias Chamaillard
Affiliations
- Sylvain Normand
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Nadine Waldschmitt
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Andreas Neerincx
- Department of Pathology, University of Cambridge
- Ruben Julio Martinez-Torres
- Division of Medicine, University College London
- Camille Chauvin
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Aurélie Couturier-Maillard
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Olivier Boulard
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Laetitia Cobret
- Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933
- Fawaz Awad
- Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933
- Ludovic Huot
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Andre Ribeiro-Ribeiro
- Division of Medicine, University College London
- Katja Lautz
- Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne
- Richard Ruez
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Myriam Delacre
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Clovis Bondu
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Martin Guilliams
- Laboratory of Immunoregulation, VIB Inflammation Research Center
- Charlotte Scott
- Laboratory of Immunoregulation, VIB Inflammation Research Center
- Anthony Segal
- Division of Medicine, University College London
- Serge Amselem
- Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933
- David Hot
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Sonia Karabina
- Sorbonne Universités, UPMC Univ Paris 06, UMR_S 933
- Erwin Bohn
- Interfakultaeres Institut für Mikrobiologie und Infektionsmedizin, Eberhard Karl Universitat Tuebingen
- Bernhard Ryffel
- CNRS, Orléans University, INEM, UMR 7355
- Lionel F. Poulin
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- Thomas A. Kufer
- Department of Immunology, Institute of Nutritional Medicine, University of Hohenheim
- Mathias Chamaillard
- University of Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019 - UMR 8204 - CIIL - Centre d′Infection et d′Immunité de Lille
- DOI
- https://doi.org/10.1038/s41467-018-07750-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Mutations in nucleotide-binding oligomerization domain protein 12 (NLRP12) are known to effect inflammatory processes. Here the authors show that NLRP12-mediated proteasomal degradation of NOD2 in monocytes promotes bacterial tolerance and colonisation in a model of enteric infection.
