Bone marrow granulomatosis: two case reports

Abstract

Bone marrow granulomatosis is not a common finding and remains a diagnostic challenge. Here below we report two bizarre but not so rare cases of bone marrow granulomatosis: bone marrow involvement by M. avium-intracellulare and reaction to intravesical administration of bacille of Calmette-Guèrin for non-muscle-invasive bladder cancer; two distinct culprits suggesting the wide range of possible causative factors of this histopathological pattern. In the discussion we provide a brief overview of causes and suggestions for a diagnostic approach.

Keywords

• Bacille of Calmette-Guèrin
• bone marrow granulomatosis
• mycobacteria
• metallosis
• pancytopenia.