Nature Communications (Jul 2019)

Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis

  • Natalie M. Niemi,
  • Gary M. Wilson,
  • Katherine A. Overmyer,
  • F.-Nora Vögtle,
  • Lisa Myketin,
  • Danielle C. Lohman,
  • Kathryn L. Schueler,
  • Alan D. Attie,
  • Chris Meisinger,
  • Joshua J. Coon,
  • David J. Pagliarini

DOI
https://doi.org/10.1038/s41467-019-11047-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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The mitochondria houses several phosphatases, but their function is not well characterized. Here, the authors show that mitochondrial phosphatase Pptc7 is important during development for proper mitochondrial function and has a role regulating protein import with the translocase subunit Timm50.