Vaccines (Sep 2021)

A Novel Approach against <i>Salmonella</i>: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers

  • Keila Y. Acevedo-Villanueva,
  • Gabriel O. Akerele,
  • Walid Ghazi Al Hakeem,
  • Sankar Renu,
  • Revathi Shanmugasundaram,
  • Ramesh K. Selvaraj

DOI
https://doi.org/10.3390/vaccines9091041
Journal volume & issue
Vol. 9, no. 9
p. 1041

Abstract

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This work discusses the present-day limitations of current commercial Salmonella vaccines for broilers and layers and explores a novel approach towards poultry vaccination using biodegradable nanoparticle vaccines against Salmonella. With the increasing global population and poultry production and consumption, Salmonella is a potential health risk for humans. The oral administration of killed or inactivated vaccines would provide a better alternative to the currently commercially available Salmonella vaccines for poultry. However, there are currently no commercial oral killed-vaccines against Salmonella for use in broilers or layers. There is a need for novel and effective interventions in the poultry industry. Polymeric nanoparticles could give way to an effective mass-administered mucosal vaccination method for Salmonella. The scope of this work is limited to polymeric nanoparticles against Salmonella for use in broilers and layers. This review is based on the information available at the time of the investigation.

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