Silver/tannic acid nanoparticles/ poly-L-lysine decorated polyvinyl alcohol-hydrogel as a hybrid wound dressing
Fatemeh Hakimi,
Hadi Balegh,
Parham Sarmadi fard,
Fahimeh Kazeminava,
Sheyda Moradi,
Mehdi Eskandari,
Zainab Ahmadian
Affiliations
Fatemeh Hakimi
Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
Hadi Balegh
Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
Parham Sarmadi fard
Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran
Fahimeh Kazeminava
Drug Applied Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Sheyda Moradi
Department of Chemistry, Faculty of Science, University of Mohagheg Ardabili, Ardabil, Iran
Mehdi Eskandari
Department of Physiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran
Zainab Ahmadian
Department of Pharmaceutics, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran; Department of Pharmaceutics, School of Pharmacy, Lorestan University of Medical Sciences, Korramabad, Iran; Corresponding author. Ardabil University of Medical Sciences, Ardabil, Iran.
Hydrogels containing antimicrobial materials have emerged as attractive platforms for wound treatment in the past decade due to their favorable bio-mimicking properties, excellent modulation of bacterial infection, and ability to minimize bacterial resistance. Herein, a hybrid combination of polyvinyl alcohol (PVA), hyperbranched poly L-lysine (L), tannic acid decorated AgNPs (AgTA NPs), loaded with Allantoin (Alla) is used to fabricate PLAg-Alla hydrogel dressing via the freeze-thaw method without use of any chemical cross-linker. The PLAg-Alla hydrogel possesses a great structure, is biodegradable, and safe, and exhibits high antibacterial potential, all required for efficient wound healing. The incorporation of AgTA and poly L-lysine (L) within the hydrogel contributes to the enhancement of antibacterial ability, as well as effectively promoting the wound healing. This hybrid hydrogel possessed favorable physicochemical features, robust antibacterial properties, and accelerated wound healing in vivo as promising dressing for the clinical application.
