Nature Communications (Jun 2021)

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice

  • Sarah Moyon,
  • Rebecca Frawley,
  • Damien Marechal,
  • Dennis Huang,
  • Katy L. H. Marshall-Phelps,
  • Linde Kegel,
  • Sunniva M. K. Bøstrand,
  • Boguslawa Sadowski,
  • Yong-Hui Jiang,
  • David A. Lyons,
  • Wiebke Möbius,
  • Patrizia Casaccia

DOI
https://doi.org/10.1038/s41467-021-23735-3
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 18

Abstract

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Myelin formation is regulated by epigenetic mechanisms and ensures proper neuronal function during development and after demyelination. Here, the authors show that TET1, a DNA hydroxymethylase, regulates myelin repair in adult mice, but is defective with aging.