SAGE Open Medical Case Reports (Sep 2024)

Dengue virus infection in hematopoietic stem cell transplant recipients: A case series and comparative literature review from dengue endemic region

  • Waseem Shahani,
  • Faiqa Fayyaz,
  • Shafaq Abdul Samad,
  • Muhammad Nizamuddin,
  • Madiha Abid,
  • Aisha Jamal,
  • Zainab Ghayas,
  • Ayesha Rafiq,
  • Abdul Hayee,
  • Dilnasheen Safdar,
  • Tasleem Farzana,
  • Uzma Zaidi

DOI
https://doi.org/10.1177/2050313X241269637
Journal volume & issue
Vol. 12

Abstract

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This case series describes the wide spectrum of clinical presentation, laboratory findings, and morbidity/mortality associated with dengue fever in hematopoietic stem cell transplant recipients, treated in a dengue endemic region. The risk of acquiring viral infections increases manifold after transplant due to the severely immunocompromised state amid conditioning toxicity and immunosuppressive therapy. The classical warning signs of dengue viremia are often masked in posttransplant patients, leading to a missed diagnosis of dengue and grave consequences observed in some of the patients. Accurate and timely diagnosis of dengue fever especially in dengue prevalent areas can prevent the unwarranted complications and reduce the morbidity and mortality associated with dengue in allogeneic/autologous transplant recipients.