UV Spectrophotometric Estimation of Acipimox inBulk and Capsule Dosage Form

A. Elphine  Prabahar; B. Thangabalan; R. Kalaichelvi; P. Vijayaraj Kumar

doi:10.1155/2009/790531

E-Journal of Chemistry (Jan 2009)

UV Spectrophotometric Estimation of Acipimox inBulk and Capsule Dosage Form

A. Elphine Prabahar,
B. Thangabalan,
R. Kalaichelvi,
P. Vijayaraj Kumar

Affiliations

A. Elphine Prabahar: Department of Pharmacy, Donbosco PG College, Vatticherukuru Mandal, Guntur-522 017, India
B. Thangabalan: Department of Pharmacy, Donbosco PG College, Vatticherukuru Mandal, Guntur-522 017, India
R. Kalaichelvi: K.C. Reddy Institute of Pharmaceuatical Sciences, Jangamguntla Palem, Medikonduru Mandal, Guntur-522 348, India
P. Vijayaraj Kumar: Bharat Instite of Pharmacy, Mangalpally Village, Ibrahimpatnam, PR Dist.-501506, India

DOI: https://doi.org/10.1155/2009/790531
Journal volume & issue: Vol. 6, no. 4
pp. 1117 – 1120

Abstract

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A new simple, rapid, accurate, sensitive and precise spectrophotometric method in ultra violet region has been developed for determination of acipimox (ACX) in bulk and capsule dosage form. Acipimox exhibited maximum absorbance at 231 nm with apparent molar absorptivity of 1.5104 × 104 in distilled water. Beer’s law was found to be obeyed in the concentration range 1-10 μg mL-1. Correlation coefficient was found to be 0.9998. The developed method was validated respect to linearity, precision, accuracy. The proposed method is useful for the routine estimation of ACX in bulk and capsule dosage form.

Published in E-Journal of Chemistry

ISSN: 0973-4945 (Print); 2090-9810 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://onlinelibrary.wiley.com/journal/2962

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