Research Progress on the Biological Activity of Ganoderic Acids in <i>Ganoderma lucidum</i> over the Last Five Years
Siyi Wang,
Longyu Wang,
Jiaolei Shangguan,
Ailiang Jiang,
Ang Ren
Affiliations
Siyi Wang
Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
Longyu Wang
Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
Jiaolei Shangguan
Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
Ailiang Jiang
Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
Ang Ren
Sanya Institute of Nanjing Agricultural University, Key Laboratory of Agricultural Environmental Microbiology Ministry of Agriculture, Department of Microbiology, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, China
Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China. The main bioactive components in G. lucidum include triterpenoids, polysaccharides, steroids, and sterols. Ganoderic acids (GAs) are one of the most abundant triterpenoids found in G. lucidum, garnering significant attention from researchers in the fields of medicine and health care. We summarize the extensive studies on the physiological function of GAs in anti-cancer, anti-inflammatory, radiation protection, anti-aging, liver protection, anti-microbial, and neuroprotection areas, among others. This review provides a comprehensive overview of the recent advances in the bioactivities and pharmacological mechanisms of GAs, aiming to delineate the current research directions and the state of the art in this field. This analysis helps to rapidly identify new bioactivities of GAs and understand their mechanisms, leading to more effective treatments for various diseases.
