Nature Communications (Sep 2020)
Pharmacologically reversible zonation-dependent endothelial cell transcriptomic changes with neurodegenerative disease associations in the aged brain
- Lei Zhao,
- Zhongqi Li,
- Joaquim S. L. Vong,
- Xinyi Chen,
- Hei-Ming Lai,
- Leo Y. C. Yan,
- Junzhe Huang,
- Samuel K. H. Sy,
- Xiaoyu Tian,
- Yu Huang,
- Ho Yin Edwin Chan,
- Hon-Cheong So,
- Wai-Lung Ng,
- Yamei Tang,
- Wei-Jye Lin,
- Vincent C. T. Mok,
- Ho Ko
Affiliations
- Lei Zhao
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Zhongqi Li
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Joaquim S. L. Vong
- Li Ka Shing Institute of Health Sciences, Faculty of Medicine, The Chinese University of Hong Kong
- Xinyi Chen
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Hei-Ming Lai
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Leo Y. C. Yan
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Junzhe Huang
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Samuel K. H. Sy
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Xiaoyu Tian
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
- Yu Huang
- School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong
- Ho Yin Edwin Chan
- Gerald Choa Neuroscience Centre, Faculty of Medicine, The Chinese University of Hong Kong
- Hon-Cheong So
- Margaret K. L. Cheung Research Centre for Management of Parkinsonism, Faculty of Medicine, The Chinese University of Hong Kong
- Wai-Lung Ng
- School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong
- Yamei Tang
- Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Wei-Jye Lin
- Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Medical Research Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
- Vincent C. T. Mok
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- Ho Ko
- Division of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-020-18249-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Blood–brain barrier dysfunction occurs in ageing and in neurodegenerative diseases. Here, the authors use scRNA-seq to identify transcriptomic changes in endothelial cell subtypes in the aged mouse brain, some of which may generalize to human and can be reversed by treatment with a GLP-1R agonist.
