Algal Phlorotannins as Novel Antibacterial Agents with Reference to the Antioxidant Modulation: Current Advances and Future Directions
Biswajita Pradhan,
Rabindra Nayak,
Prajna Paramita Bhuyan,
Srimanta Patra,
Chhandashree Behera,
Sthitaprajna Sahoo,
Jang-Seu Ki,
Alessandra Quarta,
Andrea Ragusa,
Mrutyunjay Jena
Affiliations
Biswajita Pradhan
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India
Rabindra Nayak
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India
Prajna Paramita Bhuyan
Department of Botany, Maharaja Sriram Chandra Bhanja Deo University, Baripada 757003, Odisha, India
Srimanta Patra
Cancer and Cell Death Laboratory, Department of Life Science, National Institute of Technology Rourkela, Rourkela 769008, Odisha, India
Chhandashree Behera
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India
Sthitaprajna Sahoo
Department of Botany, Berhampur University, Berhampur 760007, Odisha, India
Jang-Seu Ki
Department of Biotechnology, Sangmyung University, Seoul 03016, Korea
Alessandra Quarta
CNR-Nanotec, Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy
Andrea Ragusa
CNR-Nanotec, Institute of Nanotechnology, Via Monteroni, 73100 Lecce, Italy
Mrutyunjay Jena
Algal Biotechnology and Molecular Systematic Laboratory, Post Graduate Department of Botany, Berhampur University, Bhanja Bihar, Berhampur 760007, Odisha, India
The increasing drug resistance of infectious microorganisms is considered a primary concern of global health care. The screening and identification of natural compounds with antibacterial properties have gained immense popularity in recent times. It has previously been shown that several bioactive compounds derived from marine algae exhibit antibacterial activity. Similarly, polyphenolic compounds are generally known to possess promising antibacterial capacity, among other capacities. Phlorotannins (PTs), an important group of algae-derived polyphenolic compounds, have been considered potent antibacterial agents both as single drug entities and in combination with commercially available antibacterial drugs. In this context, this article reviews the antibacterial properties of polyphenols in brown algae, with particular reference to PTs. Cell death through various molecular modes of action and the specific inhibition of biofilm formation by PTs were the key discussion of this review. The synergy between drugs was also discussed in light of the potential use of PTs as adjuvants in the pharmacological antibacterial treatment.
