The crosstalk between cell death and pregnancy related diseases: A narrative review

Xiaowen Xie; Jiayu Liu; Jingyi Gao; Chenwei Shang; Ying Jiang; Lingyan Chen; Zhiwen Qian; Lu Liu; Danping Wu; Yun Zhang; Zhu Ru; Yan Zhang

Biomedicine & Pharmacotherapy (Jul 2024)

The crosstalk between cell death and pregnancy related diseases: A narrative review

Xiaowen Xie,
Jiayu Liu,
Jingyi Gao,
Chenwei Shang,
Ying Jiang,
Lingyan Chen,
Zhiwen Qian,
Lu Liu,
Danping Wu,
Yun Zhang,
Zhu Ru,
Yan Zhang

Affiliations

Xiaowen Xie: Wuxi Maternal and Child Health Hospital, Wuxi Medical Center of Nanjing Medical University, Wuxi, Jiangsu 214002, China; The Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi People’s Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu 214023, China
Jiayu Liu: Department of Oncology, Wuxi Maternal and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214002, China
Jingyi Gao: Suzhou Medical College, Soochow University, Suzhou, Jiangsu 215123, China
Chenwei Shang: Wuxi Maternal and Child Health Hospital, Wuxi Medical Center of Nanjing Medical University, Wuxi, Jiangsu 214002, China; The First Clinical Medical College of Nanjing Medical University, Nanjing, Jiangsu 210029, China
Ying Jiang: Department of Oncology, Wuxi Maternal and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214002, China
Lingyan Chen: Wuxi Maternal and Child Health Hospital, Wuxi Medical Center of Nanjing Medical University, Wuxi, Jiangsu 214002, China
Zhiwen Qian: Wuxi Maternal and Child Health Hospital, Wuxi Medical Center of Nanjing Medical University, Wuxi, Jiangsu 214002, China
Lu Liu: Department of Oncology, Wuxi Maternal and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214002, China
Danping Wu: Department of Oncology, Wuxi Maternal and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214002, China
Yun Zhang: Wuxi Maternal and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214002, China; Correspondenc to: Wuxi Maternal and Child Health Care Hospital,Wuxi School of Medicine, Jiangnan University, No. 48 Huaishu Road, Wuxi, Jiangsu 214002, China.
Zhu Ru: Anqing Medical College Clinical Research Center, Anqing Municipal Hospital, Anqing 246003, Anhui, China; Correspondence to: Anqing Medical College Clinical Research Center, Anqing Municipal Hospital, No. 87 Tianzhushan East Road, Anqing, Anhui 246003, China.
Yan Zhang: Department of Oncology, Wuxi Maternal and Child Health Care Hospital, Affiliated Women’s Hospital of Jiangnan University, Jiangnan University, Wuxi, Jiangsu 214002, China; Wuxi Maternal and Child Health Hospital, Wuxi Medical Center of Nanjing Medical University, Wuxi, Jiangsu 214002, China; Correspondence to: Department of Oncology, Wuxi Maternal and Child Health Care Hospital,Wuxi School of Medicine, Jiangnan University, No. 48 Huaishu Road, Wuxi, Jiangsu 214002, China.

Journal volume & issue: Vol. 176
p. 116815

Abstract

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Programmed cell death is intricately linked to various physiological phenomena such as growth, development, and metabolism, as well as the proper function of the pancreatic β cell and the migration and invasion of trophoblast cells in the placenta during pregnancy. Traditional and recently identified programmed cell death include apoptosis, autophagy, pyroptosis, necroptosis, and ferroptosis. In addition to cancer and degenerative diseases, abnormal activation of cell death has also been implicated in pregnancy related diseases like preeclampsia, gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, fetal growth restriction, and recurrent miscarriage. Excessive or insufficient cell death and pregnancy related diseases may be mutually determined, ultimately resulting in adverse pregnancy outcomes. In this review, we systematically describe the characteristics and mechanisms underlying several types of cell death and their roles in pregnancy related diseases. Moreover, we discuss potential therapeutic strategies that target cell death signaling pathways for pregnancy related diseases, hoping that more meaningful treatments will be applied in clinical practice in the future.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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