Globally, renewable energies are indispensable resources on account of RE100 and the Paris Agreement. The most developed renewable energies are photovoltaics (PV) and wind energy, and they are continuously expanding. This study aims to optimize and analyze the nuclear power plant (NPP) load-following operation in various PV conditions in a metropolitan region. With theoretically estimated power demand and PV power, a mixed-integer problem (MIP) with ramping cycle constraint (RCC) was constructed for a safe load-following operation and simulated through duck curves under various NPP load-following regions (the extreme, normal, and safe regions). The simulation showed two major results for NPP load-following. Technically, RCC successfully controlled the NPP ramp cycle and was assured to be an optimization tool for NPP operation. Numerically, NPP load-following alleviated PV intermittency to almost 50%, 30%, and 15% depending on the load-following region. However, these effects were restricted when the PV capacity rate was high, especially when it exceeded 60%. Thus, PV system capacity is recommended to be 63% of the maximum power demand in the metropolitan region with NPP load-following, and larger PV systems need more flexibility.