Using machine learning to find genes associated with sudden death

Abstract

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ObjectiveTo search for significant biomarkers associated with sudden death (SD).MethodsDifferential genes were screened by comparing the whole blood samples from 15 cases of accidental death (AD) and 88 cases of SD. The protein-protein interaction (PPI) network selects core genes that interact most frequently. Machine learning is applied to find characteristic genes related to SD. The CIBERSORT method was used to explore the immune-microenvironment changes.ResultsA total of 10 core genes (MYL1, TNNC2, TNNT3, TCAP, TNNC1, TPM2, MYL2, TNNI1, ACTA1, CKM) were obtained and they were mainly related to myocarditis, hypertrophic myocarditis and dilated cardiomyopathy (DCM). Characteristic genes of MYL2 and TNNT3 associated with SD were established by machine learning. There was no significant change in the immune-microenvironment before and after SD.ConclusionDetecting characteristic genes is helpful to identify patients at high risk of SD and speculate the cause of death.

Keywords

• sudden death
• machine learning
• molecular autopsy
• characteristic genes
• biomarkers