Nature Communications (Aug 2019)

Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis

  • Alexandra Schischko,
  • Nikolaos Kaplaneris,
  • Torben Rogge,
  • Giedre Sirvinskaite,
  • Jongwoo Son,
  • Lutz Ackermann

DOI
https://doi.org/10.1038/s41467-019-11395-3
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 9

Abstract

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Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and peptide ligations by solid phase peptide synthesis.