Nature Communications (Aug 2019)
Late-stage peptide C–H alkylation for bioorthogonal C–H activation featuring solid phase peptide synthesis
Abstract
Palladium-catalyzed late-stage diversification of structurally complex peptides has major shortcomings. Here, the authors developed a ruthenium-catalyzed C–H alkylations of peptides allowing for fluorescence labeling, late-stage diversifications and peptide ligations by solid phase peptide synthesis.