Circular RNA hsa_circ_0007121 regulates proliferation, migration, invasion, and epithelial–mesenchymal transition of trophoblast cells by miR-182-5p/PGF axis in preeclampsia

Gai Shukun; Sun Li; Wang Huiying; Yang Ping

doi:10.1515/med-2020-0230

Open Medicine (Oct 2020)

Circular RNA hsa_circ_0007121 regulates proliferation, migration, invasion, and epithelial–mesenchymal transition of trophoblast cells by miR-182-5p/PGF axis in preeclampsia

Gai Shukun,
Sun Li,
Wang Huiying,
Yang Ping

Affiliations

Gai Shukun: Department of Obstetrics, Yantai Yuhuangding Hospital, 20 Yudong Road, Zhifu District, Shandong Province, 264000, Yantai, Shandong, China
Sun Li: Department of Obstetrics, Yantai Yuhuangding Hospital, 20 Yudong Road, Zhifu District, Shandong Province, 264000, Yantai, Shandong, China
Wang Huiying: Department of Obstetrics, Yantai Yuhuangding Hospital, 20 Yudong Road, Zhifu District, Shandong Province, 264000, Yantai, Shandong, China
Yang Ping: Department of Obstetrics, Yantai Yuhuangding Hospital, 20 Yudong Road, Zhifu District, Shandong Province, 264000, Yantai, Shandong, China

DOI: https://doi.org/10.1515/med-2020-0230
Journal volume & issue: Vol. 15, no. 1
pp. 1061 – 1071

Abstract

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Mounting evidence has revealed that abnormal expression of circular RNAs play pivotal roles in many human diseases including preeclampsia (PE). While human sapiens circular RNA 0007121 (hsa_circ_0007121) has been verified to be downregulated in human placental tissues, the underlying mechanisms were still unclear. This research aims to investigate the effect and underlying mechanisms of hsa_circ_0007121 in preeclampsia.

Published in Open Medicine

ISSN: 2391-5463 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Medicine
Website: https://www.degruyter.com/journal/key/med/html

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