Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

A. Flores; S. Sandoval-Gonzalez; R. Takahashi; A. Krall; L. Sathe; L. Wei; C. Radu; J. H. Joly; N. A. Graham; H. R. Christofk; W. E. Lowry

doi:10.1038/s41467-018-07857-9

Nature Communications (Jan 2019)

Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin

A. Flores,
S. Sandoval-Gonzalez,
R. Takahashi,
A. Krall,
L. Sathe,
L. Wei,
C. Radu,
J. H. Joly,
N. A. Graham,
H. R. Christofk,
W. E. Lowry

Affiliations

A. Flores: Department of Molecular Cell and Developmental Biology, UCLA
S. Sandoval-Gonzalez: Department of Molecular Cell and Developmental Biology, UCLA
R. Takahashi: Division of Dermatology, David Geffen School of Medicine, UCLA
A. Krall: Department of Biological Chemistry, UCLA
L. Sathe: Department of Molecular Cell and Developmental Biology, UCLA
L. Wei: Department of Pharmacology, UCLA
C. Radu: Department of Pharmacology, UCLA
J. H. Joly: Department of Engineering, USC
N. A. Graham: Department of Engineering, USC
H. R. Christofk: Department of Biological Chemistry, UCLA
W. E. Lowry: Department of Molecular Cell and Developmental Biology, UCLA

DOI: https://doi.org/10.1038/s41467-018-07857-9
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 14

Abstract

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Most tumours are characterized by increased aerobic glycolytic activity. Here the authors show that elevated aerobic glycolysis is not essential for cancer initiation by testing the effect of lactate dehydrogenase depletion on the ability of hair follicle stem cells (HFSCs) to form squamous cell carcinoma (SCC) in mouse genetic models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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