Pakistan Armed Forces Medical Journal (Dec 2018)
HYPOVITAMINOSIS D, CORTICAL AND SUB-CORTICAL COGNITIVE FUNCTIONING DEFICTS IN PATIENTS WITH PARKINSON'S DISEASE DEMENTIA
Abstract
Objective: To examine vitamin D status and its association with cortical/sub-cortical cognitive functioning in patients with Parkinson’s Disease Dementia. Study Design: Cross sectional study. Place and Duration of Study: Bahawal Victoria Hospital, Civil Hospital and Nishter Hospital Pakistan during May 2016 to June 2017. Material and Methods: Fifty patients diagnosed with PDD at Bahawal Victoria Hospital, Civil Hospital and Nishter Hospital Pakistan during May 2016 until June 2017 and fifty healthy individuals participated in the study. Blood samples were examined for serum 25 hydroxy vitamin D. Following, Parkinson’s disease cognitive rating scale was administered to assess cortical and sub-cortical cognitive functioning. Results: Results showed that patients with PDD were deficient in serum 25 hydroxy vitamin D and cortical/subcortical cognitive functioning in contrast with healthy individuals. Serum 25 hydroxy Vitamin D and education level of patients with PDD were significant predictors of cortical and subcortical cognitive impairment. Conclusion: Hypovitaminosis D is a biomarker of cortical and subcortical cognitive deficits in patients with PDD.
