Robust two-degree-of-freedom control: A simulation-based approach for adults population with T1D

Abstract

Diabetes Mellitus (DM) is emerging as a global concern, affecting people from early ages to adulthood and positioning itself as one of the leading causes of mortality worldwide. The post-COVID-19 era has been characterized by notable progress in the domains of medicine, science, and engineering, creating a favorable atmosphere for the investigation of innovative solutions. The present manuscript aims to investigate the problem of glucose regulation in adults diagnosed with Type 1 Diabetes mellitus (T1D) using a two-degree-of-freedom robust controller technique. A physiological mathematical model involving individuals with T1D serves as the foundation for the proposed closed-loop technique. The control algorithm approach successfully maintains safe glycemic levels in a virtual population of 10 adults using a sophisticated, well-known physiological T1D simulator. We evaluated this with continuous 24-hour simulations. Simulation results support the practicality of the presented approach, and we further validate it using a statistical analysis that incorporates a probability density function and control variability grid analysis (CVGA). Despite being a theoretical and simulation-based methodology, the results of this study demonstrate promise, offering promising opportunities for developments in the field of artificial pancreas technology using Mexican technology.

Keywords

• Type 1 diabetes
• Two-degree-of-freedom
• Robust controller
• Physiological T1D simulator
• Biological system modeling