Nature Communications (Sep 2018)

Contribution of allelic imbalance to colorectal cancer

  • Kimmo Palin,
  • Esa Pitkänen,
  • Mikko Turunen,
  • Biswajyoti Sahu,
  • Päivi Pihlajamaa,
  • Teemu Kivioja,
  • Eevi Kaasinen,
  • Niko Välimäki,
  • Ulrika A. Hänninen,
  • Tatiana Cajuso,
  • Mervi Aavikko,
  • Sari Tuupanen,
  • Outi Kilpivaara,
  • Linda van den Berg,
  • Johanna Kondelin,
  • Tomas Tanskanen,
  • Riku Katainen,
  • Marta Grau,
  • Heli Rauanheimo,
  • Roosa-Maria Plaketti,
  • Aurora Taira,
  • Päivi Sulo,
  • Tuomo Hartonen,
  • Kashyap Dave,
  • Bernhard Schmierer,
  • Sandeep Botla,
  • Maria Sokolova,
  • Anna Vähärautio,
  • Kornelia Gladysz,
  • Halit Ongen,
  • Emmanouil Dermitzakis,
  • Jesper Bertram Bramsen,
  • Torben Falck Ørntoft,
  • Claus Lindbjerg Andersen,
  • Ari Ristimäki,
  • Anna Lepistö,
  • Laura Renkonen-Sinisalo,
  • Jukka-Pekka Mecklin,
  • Jussi Taipale,
  • Lauri A. Aaltonen

DOI
https://doi.org/10.1038/s41467-018-06132-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 9

Abstract

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In this study the authors examine the allelic imbalance (AI) landscape of colorectal cancer, reporting loss of TP53 as a driver of AI. They use CRISPR-Cas9 screens to identify 79 genes (within AI regions) regulating cell growth and identify a network of transcription factors that may contribute to colorectal tumorigenesis.