Infection and Drug Resistance (Jul 2021)
Treatment and Clinical Outcomes of Osteoarticular Infections Among Pediatrics Admitted to Jimma University Medical Center, Ethiopia: A Prospective Observational Study
Abstract
Mekonnen Damessa Mamo,1 Fekede Bekele Daba,1 Mohammed Beshir Jnr,2 Korinan Fanta1 1Department of Clinical Pharmacy, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia; 2Department of Pediatrics, Institute of Health, Jimma University, Jimma, Oromia, EthiopiaCorrespondence: Mekonnen Damessa Mamo; Korinan FantaDepartment of Clinical Pharmacy, Institute of Health, Jimma University, P.O.Box: 378, Jimma, Oromia, EthiopiaTel +251924100153; +251911598485Fax +251576617980Email [email protected]; [email protected]: Despite the high burden of osteoarticular infections in sub-Saharan Africa, there is a paucity of data regarding the osteoarticular infections management approach and clinical outcomes in the region. Hence, this study aimed to evaluate a management protocol, clinical outcomes, and its determinants among pediatric patients with osteoarticular infections.Methods: A pediatric patient admitted to Jimma University Medical Center (JUMC), Ethiopia, with a diagnosis of osteoarticular infections was enrolled prospectively from April 30 to October 30, 2019. Clinical characteristics, management modality, and in-hospital complications were recorded from admission to discharge. Data were analyzed by using SPSS v.23 and the p-value < 0.05 was considered statistically significant.Results: Among a total of 150 pediatric patients enrolled in this study, osteomyelitis was diagnosed in 111 (74%), while the rest 39 (26%) had septic arthritis. The majority 105 (70%) of the study participants were male with a mean age of 8.79 ± 4.2 years. The culture was performed for only 3.6% of the patients. Almost all (98.7%) of the patients received intravenous (IV) antibiotics, and ceftriaxone was the most common IV antibiotic used as a monotherapy 66 (44.6%) or in combination with metronidazole 47 (31.8%) or gentamicin (12.8%). Almost half (45.3%) of the patients had poor treatment outcomes. Factors associated with poor treatment outcome were comorbidity [AOR=3.3, 95% CI (1.08– 10.16)] and use of combination antibiotics [AOR=2.9, 95% CI (1.16– 7.3)]. Rural residence [AOR=0.39, 95% CI (0.168– 0.92)] and surgical interventions [AOR=0.29, 95% CI (0.006– 0.144)] were associated with good treatment outcomes.Conclusion: Almost half of pediatric patients with osteoarticular infections had poor treatment outcome. Health providers should increase the accessibility of microbiological tests and diagnostic imaging, which can guide treatment decisions and improve outcomes of patients with osteoarticular infections.Keywords: management, infections, osteomyelitis, septic arthritis, children, sub-Saharan Africa
