Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

Alexander I. Young; Fabian Wauthier; Peter Donnelly

doi:10.1038/ncomms12724

Nature Communications (Sep 2016)

Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index

Alexander I. Young,
Fabian Wauthier,
Peter Donnelly

Affiliations

Alexander I. Young: Wellcome Trust Centre for Human Genetics, University of Oxford
Fabian Wauthier: Wellcome Trust Centre for Human Genetics, University of Oxford
Peter Donnelly: Wellcome Trust Centre for Human Genetics, University of Oxford

DOI: https://doi.org/10.1038/ncomms12724
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 12

Abstract

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Common variants in the fat mass and obesity associated (FTO) gene are linked to body mass index (BMI). Using the latest UK Biobank data, this study shows novel gene x environment interactions between FTOand lifestyle factors, including frequency of alcohol consumption, sleep, and added dietary salt.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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