Nature Communications (May 2022)
MRNIP condensates promote DNA double-strand break sensing and end resection
- Yun-Long Wang,
- Wan-Wen Zhao,
- Shao-Mei Bai,
- Li-Li Feng,
- Shu-Ying Bie,
- Li Gong,
- Fang Wang,
- Ming-Biao Wei,
- Wei-Xing Feng,
- Xiao-Lin Pang,
- Cao-Litao Qin,
- Xin-Ke Yin,
- Ying-Nai Wang,
- Weihua Zhou,
- Daniel R. Wahl,
- Quentin Liu,
- Ming Chen,
- Mien-Chie Hung,
- Xiang-Bo Wan
Affiliations
- Yun-Long Wang
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Wan-Wen Zhao
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Shao-Mei Bai
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Li-Li Feng
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Shu-Ying Bie
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Li Gong
- Instrumental Analysis Research Center, Sun Yat-sen University
- Fang Wang
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Ming-Biao Wei
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Wei-Xing Feng
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Xiao-Lin Pang
- Department of Radiation Oncology, the Sixth Affiliated Hospital, Sun Yat-sen University
- Cao-Litao Qin
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Xin-Ke Yin
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- Ying-Nai Wang
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Weihua Zhou
- Department of Radiation Oncology, University of Michigan
- Daniel R. Wahl
- Department of Radiation Oncology, University of Michigan
- Quentin Liu
- Institute of Cancer Stem Cell, Dalian Medical University
- Ming Chen
- State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University
- Mien-Chie Hung
- Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center
- Xiang-Bo Wan
- Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, the Sixth Affiliated Hospital, Sun Yat-sen University
- DOI
- https://doi.org/10.1038/s41467-022-30303-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
The MRN complex is a critical sensor and processor of DNA double-strand breaks (DSBs). Here, the authors show that MRNIP forms liquid-like condensates to accelerate the MRN-mediated sensing and end resection of DSB, thereby promoting DSB repair.
