Running modulates primate and rodent visual cortex differently
John P Liska,
Declan P Rowley,
Trevor Thai Kim Nguyen,
Jens-Oliver Muthmann,
Daniel A Butts,
Jacob Yates,
Alexander C Huk
Affiliations
John P Liska
Departments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States
Declan P Rowley
Departments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States; Departments of Ophthalmology and Psychiatry & Biobehavioral Sciences, Fuster Laboratory for Cognitive Neuroscience, UCLA, Los Angeles, United States
Departments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States
Departments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States
Departments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States; Departments of Ophthalmology and Psychiatry & Biobehavioral Sciences, Fuster Laboratory for Cognitive Neuroscience, UCLA, Los Angeles, United States
When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remains unclear whether visual processing in primates might similarly change during locomotion. We therefore measured V1 activity in marmosets while they viewed stimuli on a treadmill. In contrast to mouse, running-correlated modulations of marmoset V1 were small and tended to be slightly suppressive. Population-level analyses revealed trial-to-trial fluctuations of shared gain across V1 in both species, but while strongly correlated with running in mice, gain modulations were smaller and more often negatively correlated with running in marmosets. Thus, population-wide fluctuations of V1 may reflect a common feature of mammalian visual cortical function, but important quantitative differences point to distinct consequences for the relation between vision and action in primates versus rodents.
