The role of Raptor in lymphocytes differentiation and function

Jianing Tang; Lu Yang; Fei Guan; Heather Miller; Niels Olsen Saraiva Camara; Louisa K. James; Kamel Benlagha; Masato Kubo; Steffen Heegaard; Steffen Heegaard; Pamela Lee; Jiahui Lei; Hu Zeng; Hu Zeng; Chengwei He; Zhimin Zhai; Chaohong Liu

doi:10.3389/fimmu.2023.1146628

Frontiers in Immunology (May 2023)

The role of Raptor in lymphocytes differentiation and function

Jianing Tang,
Lu Yang,
Fei Guan,
Heather Miller,
Niels Olsen Saraiva Camara,
Louisa K. James,
Kamel Benlagha,
Masato Kubo,
Steffen Heegaard,
Steffen Heegaard,
Pamela Lee,
Jiahui Lei,
Hu Zeng,
Hu Zeng,
Chengwei He,
Zhimin Zhai,
Chaohong Liu

Affiliations

Jianing Tang: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China
Lu Yang: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China
Fei Guan: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China
Heather Miller: Cytek Biosciences, R&D Clinical Reagents, Fremont, CA, United States
Niels Olsen Saraiva Camara: Department of Immunology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil
Louisa K. James: Centre for Immunobiology, Bizard Institute, Queen Mary University of London, London, United Kingdom
Kamel Benlagha: Université de Paris, Institut de Recherche Saint-Louis, EMiLy, Paris, France
Masato Kubo: Laboratory for Cytokine Regulation, Center for Integrative Medical Science (IMS), Rikagaku Kenkyusho, Institute of Physical and Chemical Research (RIKEN) Yokohama Institute, Yokohama, Japan
Steffen Heegaard: Department of Ophthalmology, Rigshospitalet Glostrup, Copenhagen, Denmark
Steffen Heegaard: Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark
Pamela Lee: Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, Hong Kong SAR, China
Jiahui Lei: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China
Hu Zeng: 0Department of Immunology, Mayo Clinic, Rochester, MN, United States
Hu Zeng: 1Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, United States
Chengwei He: 2State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macao SAR, China
Zhimin Zhai: 3Department of Hematology, The Second Hospital of Anhui Medical University, Hefei, China
Chaohong Liu: Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonostic Infectious Disease, Huazhong University of Science and Technology, Wuhan, Hubei, China

DOI: https://doi.org/10.3389/fimmu.2023.1146628
Journal volume & issue: Vol. 14

Abstract

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Raptor, a key component of mTORC1, is required for recruiting substrates to mTORC1 and contributing to its subcellular localization. Raptor has a highly conserved N-terminus domain and seven WD40 repeats, which interact with mTOR and other mTORC1-related proteins. mTORC1 participates in various cellular events and mediates differentiation and metabolism. Directly or indirectly, many factors mediate the differentiation and function of lymphocytes that is essential for immunity. In this review, we summarize the role of Raptor in lymphocytes differentiation and function, whereby Raptor mediates the secretion of cytokines to induce early lymphocyte metabolism, development, proliferation and migration. Additionally, Raptor regulates the function of lymphocytes by regulating their steady-state maintenance and activation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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