Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands

Ziyuan Song; Rachael A. Mansbach; Hua He; Kuo-Chih Shih; Ryan Baumgartner; Nan Zheng; Xiaochu Ba; Yinzhao Huang; Deepak Mani; Yun Liu; Yao Lin; Mu-Ping Nieh; Andrew L. Ferguson; Lichen Yin; Jianjun Cheng

doi:10.1038/s41467-017-00079-5

Nature Communications (Jul 2017)

Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands

Ziyuan Song,
Rachael A. Mansbach,
Hua He,
Kuo-Chih Shih,
Ryan Baumgartner,
Nan Zheng,
Xiaochu Ba,
Yinzhao Huang,
Deepak Mani,
Yun Liu,
Yao Lin,
Mu-Ping Nieh,
Andrew L. Ferguson,
Lichen Yin,
Jianjun Cheng

Affiliations

Ziyuan Song: Department of Materials Science and Engineering, University of Illinois at Urbana–Champaign
Rachael A. Mansbach: Department of Physics, University of Illinois at Urbana–Champaign
Hua He: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University
Kuo-Chih Shih: Polymer Program, Institute of Materials Science, University of Connecticut
Ryan Baumgartner: Department of Chemistry, University of Illinois at Urbana–Champaign
Nan Zheng: Department of Materials Science and Engineering, University of Illinois at Urbana–Champaign
Xiaochu Ba: Department of Chemistry, University of Illinois at Urbana–Champaign
Yinzhao Huang: Department of Chemistry, University of Illinois at Urbana–Champaign
Deepak Mani: Department of Materials Science and Engineering, University of Illinois at Urbana–Champaign
Yun Liu: Center for Neutron Research, National Institute of Standards and Technology
Yao Lin: Polymer Program, Institute of Materials Science, University of Connecticut
Mu-Ping Nieh: Polymer Program, Institute of Materials Science, University of Connecticut
Andrew L. Ferguson: Department of Materials Science and Engineering, University of Illinois at Urbana–Champaign
Lichen Yin: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University
Jianjun Cheng: Department of Materials Science and Engineering, University of Illinois at Urbana–Champaign

DOI: https://doi.org/10.1038/s41467-017-00079-5
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 8

Abstract

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Hydrogen bonding plays a major role in determining the tridimensional structure of biopolymers. Here, the authors show that control over a polypeptide conformation can be achieved by altering the donor-acceptor properties of side-chain triazole units via protonation-deprotonation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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