Nature Communications (Jun 2019)

Structural basis for the clamping and Ca2+ activation of SNARE-mediated fusion by synaptotagmin

  • Kirill Grushin,
  • Jing Wang,
  • Jeff Coleman,
  • James E. Rothman,
  • Charles V. Sindelar,
  • Shyam S. Krishnakumar

DOI
https://doi.org/10.1038/s41467-019-10391-x
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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The neuronal Ca2+-sensor Synapotagmin-1 (Syt1) interacts with SNARE proteins and lipid membranes and synchronizes neurotransmitter release in response to Ca2+-influx. Here the authors provide insights into the underlying molecular mechanism by determining the cryo-EM structure of the Syt1–SNARE complex on a lipid membrane at 10 Å resolution.