International Journal of Endocrinology (Jan 2018)

Association of HLA-B∗38:02 with Antithyroid Drug-Induced Agranulocytosis in Kinh Vietnamese Patients

  • Mai Phuong Thao,
  • Pham Vo Anh Tuan,
  • Le Gia Hoang Linh,
  • Lam Van Hoang,
  • Phan Huu Hen,
  • Le Tuyet Hoa,
  • Hoang Anh Vu,
  • Do Duc Minh

DOI
https://doi.org/10.1155/2018/7965346
Journal volume & issue
Vol. 2018

Abstract

Read online

Background. HLA-B∗38:02 has been shown to be associated with antithyroid drug-induced agranulocytosis in Asian patients. Methods. HLA-B∗38:02 was analyzed by sequence-based typing in 21 patients who developed antithyroid drug-induced agranulocytosis and in 81 controls. Results. Frequency of HLA-B∗38:02 was 52.4% in agranulocytosis patients compared to 3.7% in controls (OR = 28.6, 95% CI = 6.8–120.2). Conclusions. HLA-B∗38:02 is a significant risk factor for agranulocytosis in Kinh Vietnamese patients treated with antithyroid drug.