Mechanistic Study of Diketopiperazine Formation during Solid-Phase Peptide Synthesis of Tirzepatide

• Jingyao Wang,
• Mark R. Berglund,
• Timothy Braden,
• Matthew C. Embry,
• Martin D. Johnson,
• Stephen R. Groskreutz,
• Fareed Bhasha Sayyed,
• Sergey Vladimirovich Tsukanov,
• Timothy D. White,
• Ankur Jalan,
• Kevin D. Seibert,
• Michael E. Kopach

Affiliations

Jingyao Wang

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Mark R. Berglund

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Timothy Braden

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Matthew C. Embry

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Martin D. Johnson

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Stephen R. Groskreutz

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Fareed Bhasha Sayyed

Synthetic Molecule Design & Development, Eli Lilly Services India Pvt. Ltd., Bengaluru, India

Sergey Vladimirovich Tsukanov

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Timothy D. White

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Ankur Jalan

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Kevin D. Seibert

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States

Michael E. Kopach

Synthetic Molecule Design and Development, Eli Lilly and Company, Indianapolis, Indiana, United States