SAMBADENA Hyperpolarization of 13C‐Succinate in an MRI: Singlet‐Triplet Mixing Causes Polarization Loss
Stephan Berner,
Andreas B. Schmidt,
Mirko Zimmermann,
Dr. Andrey N. Pravdivtsev,
Dr. Stefan Glöggler,
Prof. Dr. Dr. h.c. Jürgen Hennig,
PD Dr. Dominik von Elverfeldt,
Prof. Dr. Jan‐Bernd Hövener
Affiliations
Stephan Berner
Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg Killianstraße 5a 79106 Freiburg Germany
Andreas B. Schmidt
Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg Killianstraße 5a 79106 Freiburg Germany
Mirko Zimmermann
Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg Killianstraße 5a 79106 Freiburg Germany
Dr. Andrey N. Pravdivtsev
Department of Radiology and Neuroradiology, Section Biomedical Imaging, MOIN CC, University Medical Center Schleswig-Holstein University of Kiel Am Botanischen Garten 14 24118 Kiel Germany
Dr. Stefan Glöggler
Max Planck Institute for Biophysical Chemistry Am Fassberg 11 37077 Göttingen Germany
Prof. Dr. Dr. h.c. Jürgen Hennig
Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg Killianstraße 5a 79106 Freiburg Germany
PD Dr. Dominik von Elverfeldt
Department of Radiology, Medical Physics, Medical Center – University of Freiburg, Faculty of Medicine University of Freiburg Killianstraße 5a 79106 Freiburg Germany
Prof. Dr. Jan‐Bernd Hövener
Department of Radiology and Neuroradiology, Section Biomedical Imaging, MOIN CC, University Medical Center Schleswig-Holstein University of Kiel Am Botanischen Garten 14 24118 Kiel Germany
Abstract The signal enhancement provided by the hyperpolarization of nuclear spins of biological molecules is a highly promising technique for diagnostic imaging. To date, most 13C‐contrast agents had to be polarized in an extra, complex or cost intensive polarizer. Recently, the in situ hyperpolarization of a 13C contrast agent to >20 % was demonstrated without a polarizer but within the bore of an MRI system. This approach addresses some of the challenges of MRI with hyperpolarized tracers, i. e. elevated cost, long production times, and loss of polarization during transfer to the detection site. Here, we demonstrate the first hyperpolarization of a biomolecule in aqueous solution in the bore of an MRI at field strength of 7 T within seconds. The 13C nucleus of 1‐13C, 2,3‐2H2‐succinate was polarized to 11 % corresponding to a signal enhancement of approximately 18.000. Interesting effects during the process of the hydrogenation reaction which lead to a significant loss of polarization have been observed.
