Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern

Xiaoqi Yu; Dong Wei; Wenxin Xu; Chuanmiao Liu; Wentian Guo; Xinxin Li; Wei Tan; Leshan Liu; Xinxin Zhang; Jieming Qu; Zhitao Yang; Erzhen Chen

doi:10.1038/s41467-022-29477-0

Nature Communications (Apr 2022)

Neutralizing activity of BBIBP-CorV vaccine-elicited sera against Beta, Delta and other SARS-CoV-2 variants of concern

Xiaoqi Yu,
Dong Wei,
Wenxin Xu,
Chuanmiao Liu,
Wentian Guo,
Xinxin Li,
Wei Tan,
Leshan Liu,
Xinxin Zhang,
Jieming Qu,
Zhitao Yang,
Erzhen Chen

Affiliations

Xiaoqi Yu: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Dong Wei: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Wenxin Xu: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Chuanmiao Liu: Department of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Key Laboratory of Immunology in Chronic Diseases, First Affiliated Hospital of Bengbu Medical College
Wentian Guo: Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Xinxin Li: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Wei Tan: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Leshan Liu: Clinical Research Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Xinxin Zhang: Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Jieming Qu: Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Zhitao Yang: Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Erzhen Chen: Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-29477-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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Variants of SARS-CoV-2 present the potential for differential response and performance to delivered vaccine regimens. Here the authors characterise the neutralising antibody response to the inactivated SARS-CoV-2 vaccine BBIBP-CorV and assess functionality against a range of key SARS-CoV2 variants.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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