Nature Communications (Jul 2021)
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization
- Lijuan Zhang,
- Kai Zhang,
- Jieyou Zhang,
- Jinrong Zhu,
- Qing Xi,
- Huafeng Wang,
- Zimu Zhang,
- Yingnan Cheng,
- Guangze Yang,
- Hongkun Liu,
- Xiangdong Guo,
- Dongmei Zhou,
- Zhenyi Xue,
- Yan Li,
- Qi Zhang,
- Yurong Da,
- Li Liu,
- Zhinan Yin,
- Zhi Yao,
- Rongxin Zhang
Affiliations
- Lijuan Zhang
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Kai Zhang
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Jieyou Zhang
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Jinrong Zhu
- Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University
- Qing Xi
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Huafeng Wang
- School of Life Science, Shanxi Normal University
- Zimu Zhang
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Yingnan Cheng
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Guangze Yang
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Hongkun Liu
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Xiangdong Guo
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Dongmei Zhou
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Zhenyi Xue
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Yan Li
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Qi Zhang
- Institute of Integrative Medicines for Acute Abdominal Diseases, Nankai Hospital
- Yurong Da
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Li Liu
- Department of Radiology, The University of Texas Southwestern Medical Center
- Zhinan Yin
- The First Affiliated Hospital, Biomedical Translation Research Institute and Guangdong Province Key Laboratory of Molecular Immunology and Antibody Engineering, Jinan University
- Zhi Yao
- Key Laboratory of Immune Microenvironment and Diseases (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University
- Rongxin Zhang
- Guangdong Province Key Laboratory for Biotechnology Drug Candidates, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University
- DOI
- https://doi.org/10.1038/s41467-021-24610-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1-like function.
