A case of severe combined pathology in a late premature infant with hypoxic-ischemic damage to the central nervous system

Abstract

A clinical observation of severe combined pathology in a newborn child with congenital hypothyroidism against the background of hypoxic-ischemic damage to the central nervous system is presented. Thanks to an early screening examination for congenital hypothyroidism, on the second day of life, the child was promptly prescribed levothyroxine replacement therapy against the background of treatment of concomitant pathology, which led to positive dynamics in the course of the disease and prevented the progression of hypoxic symptoms. ischemic damage to the central nervous system. An adverse effect on the fetus of maternal pathology (acute respiratory viral infection, bacterial vaginosis, candidiasis, bacteriuria) has been demonstrated. The presence of the above factors subsequently led to a severe course of the neonatal period in a child with congenital hypothyroidism and the development of severe concomitant pathology. Early diagnosis of congenital hypothyroidism with immediate prescription of replacement therapy makes it possible to prevent the development of mental retardation in this cohort of newborns. In the future, systematic monitoring of the child by a pediatrician and endocrinologist is required, with dose adjustment of the drug if necessary.

Keywords

• congenital hypothyroidism
• perinatal damage to the central nervous system
• thyroid status