Nature Communications (Apr 2021)
RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways
- Victoria Gudiño,
- Sebastian Öther-Gee Pohl,
- Caroline V. Billard,
- Patrizia Cammareri,
- Alfonso Bolado,
- Stuart Aitken,
- David Stevenson,
- Adam E. Hall,
- Mark Agostino,
- John Cassidy,
- Colin Nixon,
- Alex von Kriegsheim,
- Paz Freile,
- Linda Popplewell,
- George Dickson,
- Laura Murphy,
- Ann Wheeler,
- Malcolm Dunlop,
- Farhat Din,
- Douglas Strathdee,
- Owen J. Sansom,
- Kevin B. Myant
Affiliations
- Victoria Gudiño
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Sebastian Öther-Gee Pohl
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Caroline V. Billard
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Patrizia Cammareri
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Alfonso Bolado
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Stuart Aitken
- MRC Human Genetics Unit, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- David Stevenson
- Cancer Research UK Beatson Institute, Garscube Estate
- Adam E. Hall
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Mark Agostino
- School of Pharmacy and Biomedical Sciences, Curtin Health and Innovation Research Institute, Curtin University
- John Cassidy
- Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
- Colin Nixon
- Cancer Research UK Beatson Institute, Garscube Estate
- Alex von Kriegsheim
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Paz Freile
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Linda Popplewell
- School of Biological Sciences, Royal Holloway - University of London
- George Dickson
- School of Biological Sciences, Royal Holloway - University of London
- Laura Murphy
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Ann Wheeler
- Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital
- Malcolm Dunlop
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Farhat Din
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- Douglas Strathdee
- Cancer Research UK Beatson Institute, Garscube Estate
- Owen J. Sansom
- Cancer Research UK Beatson Institute, Garscube Estate
- Kevin B. Myant
- Cancer Research UK Edinburgh Centre, MRC Institute of Genetics & Molecular Medicine, The University of Edinburgh, Western General Hospital
- DOI
- https://doi.org/10.1038/s41467-021-22531-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
RAC1 is a downstream target of the Wnt signaling that promotes intestinal stem cell expansion and tumorigenesis. Here, the authors identify the specific splice variant RAC1B as an important mediator of colorectal tumourigenesis and a potential target for enhancing the efficacy of EGFR inhibitor treatment.
