Nature Communications (Dec 2017)
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission
- Danielle O. Sambo,
- Min Lin,
- Anthony Owens,
- Joseph J. Lebowitz,
- Ben Richardson,
- Darin A. Jagnarine,
- Madhur Shetty,
- Meghan Rodriquez,
- Taiwo Alonge,
- Mishaal Ali,
- Jonathan Katz,
- Long Yan,
- Marcelo Febo,
- L. Keith Henry,
- Adriaan W. Bruijnzeel,
- Lynette Daws,
- Habibeh Khoshbouei
Affiliations
- Danielle O. Sambo
- Department of Neuroscience, University of Florida
- Min Lin
- Department of Neuroscience, University of Florida
- Anthony Owens
- Department of Cellular & Integrative Physiology, University of Texas Health Science Center at San Antonio
- Joseph J. Lebowitz
- Department of Neuroscience, University of Florida
- Ben Richardson
- Department of Neuroscience, University of Florida
- Darin A. Jagnarine
- Department of Psychiatry, University of Florida
- Madhur Shetty
- Department of Biomedical Sciences, University of North Dakota
- Meghan Rodriquez
- Department of Biomedical Sciences, University of North Dakota
- Taiwo Alonge
- Department of Neuroscience, University of Florida
- Mishaal Ali
- Department of Neuroscience, University of Florida
- Jonathan Katz
- Psychobiology Section, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health
- Long Yan
- Max Plank Institute for Neuroscience Jupiter
- Marcelo Febo
- Department of Psychiatry, University of Florida
- L. Keith Henry
- Department of Biomedical Sciences, University of North Dakota
- Adriaan W. Bruijnzeel
- Department of Psychiatry, University of Florida
- Lynette Daws
- Department of Cellular & Integrative Physiology, University of Texas Health Science Center at San Antonio
- Habibeh Khoshbouei
- Department of Neuroscience, University of Florida
- DOI
- https://doi.org/10.1038/s41467-017-02087-x
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
The dopamine transporter (DAT), a regulator of dopamine homeostasis in the brain, and sigma-1 receptor (σ1R), an endoplasmic reticulum membrane protein, are both implicated in drug addiction. In this work, the authors investigate how σ1R modulates DAT response to methamphetamine.
