NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

Kyrie Pappas; Tiphaine C. Martin; Andrew L. Wolfe; Christie B. Nguyen; Tao Su; Jian Jin; Hanina Hibshoosh; Ramon Parsons

doi:10.1038/s42003-021-01825-8

Communications Biology (Mar 2021)

NOTCH and EZH2 collaborate to repress PTEN expression in breast cancer

Kyrie Pappas,
Tiphaine C. Martin,
Andrew L. Wolfe,
Christie B. Nguyen,
Tao Su,
Jian Jin,
Hanina Hibshoosh,
Ramon Parsons

Affiliations

Kyrie Pappas: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Tiphaine C. Martin: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Andrew L. Wolfe: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Christie B. Nguyen: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Tao Su: Department of Pathology and Cell Biology, Columbia University Medical Center
Jian Jin: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai
Hanina Hibshoosh: Department of Pathology and Cell Biology, Columbia University Medical Center
Ramon Parsons: Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s42003-021-01825-8
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 13

Abstract

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Pappas et al. show that the combination of NOTCH and EZH2 alterations drive transcriptional repression of PTEN through reversible epigenetic modification of the PTEN promoter. These results suggest an actionable target for treating poor-prognosis breast cancer.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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