Nature Communications (Nov 2022)
Differential compartmentalization of myeloid cell phenotypes and responses towards the CNS in Alzheimer’s disease
- Camila Fernández Zapata,
- Ginevra Giacomello,
- Eike J. Spruth,
- Jinte Middeldorp,
- Gerardina Gallaccio,
- Adeline Dehlinger,
- Claudia Dames,
- Julia K. H. Leman,
- Roland E. van Dijk,
- Andreas Meisel,
- Stephan Schlickeiser,
- Desiree Kunkel,
- Elly M. Hol,
- Friedemann Paul,
- Maria Kristina Parr,
- Josef Priller,
- Chotima Böttcher
Affiliations
- Camila Fernández Zapata
- Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
- Ginevra Giacomello
- Institute of Pharmacy, Freie Universität Berlin
- Eike J. Spruth
- Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Jinte Middeldorp
- Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University
- Gerardina Gallaccio
- Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
- Adeline Dehlinger
- Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
- Claudia Dames
- Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin
- Julia K. H. Leman
- Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Roland E. van Dijk
- Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University
- Andreas Meisel
- Department of Neurology and Experimental Neurology, Charité-Universitätsmedizin Berlin
- Stephan Schlickeiser
- Institute of Medical Immunology, BIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- Desiree Kunkel
- Flow & Mass Cytometry Core Facility, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
- Elly M. Hol
- Department of Translational Neuroscience, University Medical Center Utrecht Brain Center, Utrecht University
- Friedemann Paul
- Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
- Maria Kristina Parr
- Institute of Pharmacy, Freie Universität Berlin
- Josef Priller
- Department of Neuropsychiatry and Laboratory of Molecular Psychiatry, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
- Chotima Böttcher
- Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin
- DOI
- https://doi.org/10.1038/s41467-022-34719-2
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Multiple state-of-the-art analyses of immune cells in 117 blood, 117 cerebrospinal fluid, 13 choroid plexus and 13 brain parenchyma samples reveal differential characteristics of immune cells in different body compartments and different diseases.
