Nature Communications (Nov 2020)

In vitro-transcribed antigen receptor mRNA nanocarriers for transient expression in circulating T cells in vivo

  • N. N. Parayath,
  • S. B. Stephan,
  • A. L. Koehne,
  • P. S. Nelson,
  • M. T. Stephan

DOI
https://doi.org/10.1038/s41467-020-19486-2
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Ex vivo engineering of antigen-specific T cells has shown therapeutic efficacy but can be costly and scarce. Here the authors show that in vitro-transcribed antigen receptor mRNA packaged in nanocarriers can directly induce, in vivo, transient their expression in circulating T cells to provide therapeutic effects in mouse models of cancer or viral infection.