Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium

Julie Joseph; Emmanuelle S. Ametepe; Naveen Haribabu; Gerard Agbayani; Lakshmi Krishnan; Alexandre Blais; Subash Sad

doi:10.1038/ncomms12748

Nature Communications (Sep 2016)

Inhibition of ROS and upregulation of inflammatory cytokines by FoxO3a promotes survival against Salmonella typhimurium

Julie Joseph,
Emmanuelle S. Ametepe,
Naveen Haribabu,
Gerard Agbayani,
Lakshmi Krishnan,
Alexandre Blais,
Subash Sad

Affiliations

Julie Joseph: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa
Emmanuelle S. Ametepe: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa
Naveen Haribabu: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa
Gerard Agbayani: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa
Lakshmi Krishnan: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa
Alexandre Blais: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa
Subash Sad: Department of Biochemistry, Faculty of Medicine, Microbiology, and Immunology, University of Ottawa

DOI: https://doi.org/10.1038/ncomms12748
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 14

Abstract

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FoxO3a signalling has limited influence over acute bacterial infection. Here the authors show that FoxO3a promotes survival of mice in response to chronic Salmonellatyphimurium infection by restraining oxidative stress and ERK signalling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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