Nature Communications (Mar 2022)
The Oligodendrocyte Transcription Factor 2 OLIG2 regulates transcriptional repression during myelinogenesis in rodents
- Kunkun Zhang,
- Shaoxuan Chen,
- Qihua Yang,
- Shuanghui Guo,
- Qiang Chen,
- Zhixiong Liu,
- Li Li,
- Mengyun Jiang,
- Hongda Li,
- Jin Hu,
- Xu Pan,
- Wenbo Deng,
- Naian Xiao,
- Bo Wang,
- Zhan-xiang Wang,
- Liang Zhang,
- Wei Mo
Affiliations
- Kunkun Zhang
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Shaoxuan Chen
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Qihua Yang
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Shuanghui Guo
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Qiang Chen
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Zhixiong Liu
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Li Li
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Mengyun Jiang
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Hongda Li
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Jin Hu
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Xu Pan
- School of Pharmaceutical Sciences, Xiamen University, Xiamen
- Wenbo Deng
- Xiamen Key Laboratory of Brain Center, the First Affiliated Hospital of Xiamen University
- Naian Xiao
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Bo Wang
- School of Life Sciences, Innovation Center for Cell Signaling Network, Xiamen University
- Zhan-xiang Wang
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Liang Zhang
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- Wei Mo
- Department of Neurosurgery and Department of Neuroscience, the First Affiliated Hospital of Xiamen University, State Key Laboratory of Cellular Stress Biology, School of Medicine, Xiamen University
- DOI
- https://doi.org/10.1038/s41467-022-29068-z
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Transcription factors regulate gene programs during myelination. Here, the authors show that the Oligodendrocyte Transcription Factor 2 (OLIG2) regulates the differentiation of oligodendrocyte progenitor cells into immature oligodendrocytes via SETDB1 during myelination and remyelination in rodents.
