Nature Communications (Feb 2018)

Sheep genome functional annotation reveals proximal regulatory elements contributed to the evolution of modern breeds

  • Marina Naval-Sanchez,
  • Quan Nguyen,
  • Sean McWilliam,
  • Laercio R. Porto-Neto,
  • Ross Tellam,
  • Tony Vuocolo,
  • Antonio Reverter,
  • Miguel Perez-Enciso,
  • Rudiger Brauning,
  • Shannon Clarke,
  • Alan McCulloch,
  • Wahid Zamani,
  • Saeid Naderi,
  • Hamid Reza Rezaei,
  • Francois Pompanon,
  • Pierre Taberlet,
  • Kim C. Worley,
  • Richard A. Gibbs,
  • Donna M. Muzny,
  • Shalini N. Jhangiani,
  • Noelle Cockett,
  • Hans Daetwyler,
  • James Kijas

DOI
https://doi.org/10.1038/s41467-017-02809-1
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

The domestication of plants and animals causes genomic changes underlying various morphologic, physiologic and behavioral changes. Here, Naval-Sanchez et al. provide a ChIP-Seq validated comparative functional annotation of the sheep genome, and show widespread evolution of proximal regulatory elements.