Use of Oxidative Coupling Strategy as a Means to Increase In Vitro Antioxidant Activity of Vanillin Derivatives

Abstract

The aim of this study was to investigate the antioxidant properties in vitro of three different vanillic dimmers (Compounds 1a–c). They were synthesized through an oxidative coupling strategy in good yields. The targeted compounds were found to be highly active for the total antioxidant assay, as well as for the lipid peroxidation test. All investigated compounds exhibited superior or comparable antioxidant capacity in comparison to precursor vanillin, proving that oxidative coupling is a great strategy to increase the antioxidant behavior of vanillin derivatives.

Keywords

• vanillic dimers
• oxidative coupling
• antioxidant activity