Фармакокинетика и Фармакодинамика (May 2023)

Effect of GK-1 NGF Loop 4 Dipeptide Mimetic on tumor growth and metastasis of Lewis lung carcinoma in experiment on male C57BL/6 mice

  • L. P. Kovalenko,
  • R. V. Zhurikov,
  • P. Yu. Povarnina,
  • A. V. Tarasiuk

DOI
https://doi.org/10.37489/2587-7836-2023-1-45-50
Journal volume & issue
Vol. 0, no. 1
pp. 45 – 50

Abstract

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Article describes results of study of antitumor and antimetastatic action of dipeptide mimetic of the nerve growth factor amide N-monosuccinyl-L-glutamyl-L-lysine (compound GK-1) in comparison with gemcitabine. Two injections of gemcitabine in total dose of 100 mg/kg resulted in significant tumor growth inhibition by 60–61% on 7th, 9th and 15th days of tumor development. Course administration of GK-1 in doses of 10 mk/kg from 2nd to 15th day of tumor development resulted in significant tumor growth inhibition by 57,8 %. Metastasis inhibition index (MII) of gemcitabine was 75,8 %. MII of GK-1 in doses of 10 mg/kg or 30 mg/kg was 44,9 % and 47,7 % accordingly. It was shown that GK-1 in studied range of doses exerts antimetastatic activity.

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