Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features

Yannic C. Bartsch; Carolin Loos; Evan Rossignol; Jesse M. Fajnzylber; Dansu Yuan; Anchalee Avihingsanon; Sasiwimol Ubolyam; Thidarat Jupimai; Bernard Hirschel; Jintanat Ananworanich; Douglas A. Lauffenburger; Jonathan Z. Li; Galit Alter; Boris Julg

doi:10.1128/mBio.00170-21

mBio (Apr 2021)

Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features

Yannic C. Bartsch,
Carolin Loos,
Evan Rossignol,
Jesse M. Fajnzylber,
Dansu Yuan,
Anchalee Avihingsanon,
Sasiwimol Ubolyam,
Thidarat Jupimai,
Bernard Hirschel,
Jintanat Ananworanich,
Douglas A. Lauffenburger,
Jonathan Z. Li,
Galit Alter,
Boris Julg

Affiliations

Yannic C. Bartsch: Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
Carolin Loos: Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
Evan Rossignol: Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
Jesse M. Fajnzylber: Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Dansu Yuan: Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
Anchalee Avihingsanon: HIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Sasiwimol Ubolyam: HIV-NAT, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand
Thidarat Jupimai: Center of Excellence for Pediatric Infectious Diseases and Vaccines, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Bernard Hirschel: Division of Infectious Diseases, Geneva University Hospital, Geneva, Switzerland
Jintanat Ananworanich: Department of Global Health, University of Amsterdam, Amsterdam, The Netherlands
Douglas A. Lauffenburger: Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Jonathan Z. Li: Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Galit Alter: Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA
Boris Julg: Ragon Institute of MGH, MIT and Harvard, Cambridge, Massachusetts, USA

DOI: https://doi.org/10.1128/mBio.00170-21
Journal volume & issue: Vol. 12, no. 2

Abstract

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Plasma viremia reoccurs in most HIV-infected individuals once antiretroviral therapy is interrupted, and interindividual differences in the kinetics of viral rebound have been associated with virological and immunological factors. Antibody features, including Fc functionality and Fc glycosylation, have been identified as sensitive surrogates for disease activity in multiple diseases.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

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